|
KMID : 0361020000430070751
|
|
Korean Journal of Otolaryngology - Head and Neck Surgery
2000 Volume.43 No. 7 p.751 ~ p.757
|
|
|
Angiogenesis and p53 Mutation in Oral and Oropharyngeal Squamous Cell Carcinoma
|
|
Sun Dong-Il
Kim Min-Sik
Cho Seung-Ho
Kim Byung-Kee
Suh Byung-Do
|
|
|
Abstract
|
|
|
Background and Objectives : It is well known that microvessel density (MVD) and p53 gene mutation are
significantly correlated with tumor behaviors in some types of cancer ; however, some studies have
reported a lack of relationship among MVD, p53 gene mutation and tumor behavior in oral cancers. The
objective of this study was to identify putative association between p53 gene mutation and microvessel
density (MVD) and to evaluate the usefulness of this association in deciding the therapeutic plan.
Materials and Methods : In 25 tumor specimens of oral squamous cell carcinoma, microvessel density
(MVD) was analysed by immunohistochemical staining with CD-31 monoclonal antibody, and p53 mutation
was examined in exon 5 through 8 by PCR-SSCP and sequencing analysis.
Results : Seven of the 25 patients had mutation in exon 5 to 8 and all the mutations were missense mutation.
The mean of MVD in the mutant group was 13.3±2.80 and that of MVD in the wild type group was 18.6±1.16.
An inverse relationship was seen between MVD and p53 mutation(p=0.047). The p53 gene mutation was frequently
found in exon 5.
Conclusion : MVD and p53 gene mutation were not associated with respect to stage,
cervical metastasis and recurrence of the oral and oropharyngeal cancer. Angiogenesis of oral squamous
cell might not be regulated by p53, but might be regulated by other factors.
|
|
|
KEYWORD
|
|
|
Angiogenesis, MVD, p53mutation, Oral and oropharyngeal squamous cell carcinoma
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|